The following is a partial list of Nexgen Information Systems clients.

Non-profits

• The National AIDS Fund
• Industry Initiative for Science and Math Education
• Rape Crisis Services of Greater Lowell
• The Clean Water Network
• The Department of Commerce Day Care Center
• Community Technology Center's Network
• The Kennedy Institute

Small Businesses

• Development InfoStructure (devis)
• Tradeloop.com
• CitySoft
• Vendorbase.com